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university Rennes1 university Rennes1

Institute of Genetics and Development of Rennes



 
 
CANINE GENOMICS & GENETICS PROJECTS


Dogs share many similar diseases with humans and appear to be becoming the geneticist's best friend. The purebred dog is now a popular and useful model organism for genetic studies of disease and more recently, behavior. Its popularity stems from the history of breeding practices that have produced and maintain the phenotypic diversity of dog breeds, combined with relative intra-breed genetic homogeneity. All these characteristics are now used for successful linkage-based and association-based approaches for gene-mapping. Dog genetics is going to tell us more about human and tell us more about biology in general.

At the University of Rennes1, CNRS-UMR6290, France, we use the canine model for:
     Genome Annotation and Directional selection studies
     The functional and genetic analysis of the canine olfactory receptors (OR) repertoire
     Comparative genomics studies : AUTOGRAPH [Comparative genomics web server]
     The dog model for the study of genetic diseases: A dedicated web site here:


  Genome Annotation and Directional selection studies
    Novel origins of copy number variation in the dog genome [Berglund et al.] Genome Biology 2012
    [Full Text] [PubMed] [CNV Database]
    Identification of loci governing common and rare phenotypic traits in dog breeds using selection mapping [Vaysse et al.] PLos Genetics 2011
    [Full Text] [PubMed] [Metrics] [Supplemental Data]

    Annotation of the domestic dog genome sequence: finding the missing genes [Derrien T. et al.] Mam. Genome, 2011
    [PubMed]
    Revisiting the missing protein-coding gene catalog of the domestic dog [Derrien T. et al.] BMC Genomics, 2009
    [Full Text] [PubMed]
    Assessment and impact of intra-breed stratification on SNP-based association studies [Quignon P. et al.] PLos ONE 2007
    [Full Text] [PubMed] [Metrics]

  Functional and genetic analysis of the canine olfactory receptors (OR) repertoire
    Olfactory receptors, to which odorant molecules specifically bind, are encoded by the largest gene family yet identified in the mammalian genome. We investigate polymorphisms due to the possible existence of multiple alleles dispersed in different dog breeds by carrying out a survey of the sequences of the olfactory receptor genes.

    Genetic diversity of canine olfactory receptors [Robin S. et al.] BMC Genomics, 2009
    [Full Text]
    The dog and rat olfactory receptor repertoires [Quignon P. et al.] Genome Biol., 2005
    [Read more...]
    Olfactory receptor sequence polymorphism within and between breeds of dogs [Tacher S. et al.] J. Hered., 2005
    [Read more...]
    Comparison of the canine and human olfactory receptor gene repertoire [Quignon P. et al.] Genome Biol., 2003
    [Full Text]

  Development of bioinformatic tools
    AutoGRAPH : a web server for automating and visualizing comparative genome maps [Derrien T. et al.] Bioinformatics 2007
    [AUTOGRAPH Web server]

    CRH_Server : Comparative and Radiation Hybrid Server for the Canine Genome [Hitte C. et al.] Bioinformatics 2004
    [Web server]

    DogDB : Canine Genome Maps Database
    [enter here]


  Genomic resources for the canine model
    Dog Genome Sequencing Project [Lindblad-Toh K. et al.]; Nature, 2005
    [Enter]
    A 10,000 Canine Gene RH Map [Hitte C. et al.] ; Nat. Rev. Genet., 2005
    [Enter]
    An integrated FISH-RH Map  [Breen M.*, Hitte C.*, Lorentzen T.* et al.]; BMC Genomics, 2004
    [Enter]
    A 1-Mb Resolution RH map of the canine genome [Guyon R. et al. ]; Proc. Natl. Acad. Sci. USA, 2003
    [Enter]


Questions or comments : contact
hitte[@]univ-rennes1.fr


 

Last updated : April, 2013  
©  Copyright 2005-2013 UMR6290 CNRS  

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