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 dog genetics

- These data are Additional data files for :

The Dog and Rat Olfactory Receptor Repertoires

  Pascale Quignon1,4, Mathieu Giraud2, Maud Rimbault1, Patricia Lavigne1, Sandrine Tacher1, Emmanuelle Morin2, Elodie Retout2,
Anne-Sophie Valin2, Kerstin Lindblad-Toh3, Jacques Nicolas2 and Francis Galibert1

Genome Biol. 2005;6(10) Sep 28. [-pubmed-] [-full paper-]


Dogs and rats have a highly developed capability to detect and identify odorant molecules, even at minute concentrations. Previous analyses have shown that the olfactory receptors (ORs) that specifically bind odorant molecules are encoded by the largest gene family sequenced in mammals so far.


We identified five amino acid patterns characteristic of ORs in the recently sequenced boxer dog and brown Norway rat genomes. Using these patterns, we retrieved 1,094 dog genes and 1,493 rat genes from these shotgun sequences. The retrieved sequences constitute the olfactory receptor repertoires of these two animals. Subsets of 20.3% (for the dog) and 19.5% (for the rat) of these genes were annotated as pseudogenes as they had one or several mutations interrupting their open reading frames. We performed phylogenetic studies and organized these two repertoires into classes, families and subfamilies.


We have established a complete or almost complete list of OR genes in the dog and the rat and have compared the sequences of these genes within and between the two species. Our results provide insight into the evolutionary development of these genes and the local amplifications that have led to the specific amplification of many subfamilies. We have also compared the human and rat ORs with the human and mouse OR repertoires.

  • Chromosomal localisation of canine OR genes and pseudogenes. Clusters are named following their position in megabases from the top of each chromosome [Additional_data_file_1.xls]
  • Chromosomal localisation of rat OR genes and pseudogenes. Clusters are named following their position in megabases from the top of each chromosome [Additional_data_file_2.xls]
  • Number of rat and dog OR genes and pseudogenes per family and subfamily. Families 2 to 21 belong to ClassII and families 51 to 57 to ClassI [Additional_data_file_3.xls]

1Pr Francis GALIBERT group at CNRS-University of Rennes1 - Rennes France
2Pr Jacques NICOLAS group at IRISA-University of Rennes1 - Rennes France
3Dr Kerstin LINDBLAD-TOH group at the BROAD Institute of MIT&Harvard - Cambridge USA
4current address : NIH/NHGRI/50 South Drive, MSC 8000, Bethesda, MD 20892-8000, USA